Epidemiology of Carbapenemase-Producing Enterobacteriaceae (CPE) in Western Australian (WA) healthcare facilities, 2012 to 2022
Khui Hung Lee1, Liana Varrone1, Inutu Kashina1, Olivia Kamau1, Lisa Nicolaou1, Rebecca McCann11Infection Prevention, Policy & Surveillance Unit, Communicable Disease Control Directorate, Western Australia Department, East Perth, Western Australia, Australia
The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) is increasing worldwide. The purpose of this study is to review the epidemiology of CPE in Western Australian (WA) healthcare facilities from 2012 to 2022.
Data were extracted from CPE notifications made to WA Health. CPE cases were grouped by gender, specimen isolate, specimen type, species type, IMP and non-IMP, and carbapenemase gene families. Non-IMP CPE cases were reviewed to determine overseas travel history in the last four years and hospitalisation history in the last 12 months. All analyses were conducted using RStudio.
182 CPEs were reported to WA Health. Patients were mainly male (53.8%) and more than 59% were ≥ 60 years old. Majority of CPE samples were isolated from a clinical specimen (n=127, 69.8%). Most CPE (89, 48.9%) were collected from urine samples, 10 (5.5%) from blood cultures, 9 (4.9%) from sputum specimens and the remainder (74, 40.7%) were swabs, fluids and tissues from various body sites. Klebsiella spp. (n = 48) and Escherichia coli (n = 47) were the dominant species. Half of the carbapenemase families were IMP (n = 91) and half of them were non-IMP (n = 91) with NDM enzymes predominated overall (n = 40, 44%). From 2018 to 2022, a decreasing trend was observed for IMP. Travel abroad was the most common risk factor for acquisition of non-IMP CPE, accounting for 65.9% of cases.
CPE remains low in WA healthcare facilities. Half cases were non-IMP CPE, with recent travel abroad as the main risk factor for acquisition.
Biography
Lisa is an acting Program Manager for Infection Prevention Policy ＆ Surveillance Unit (IPPSU) at Communicable Disease Control Directorate, Department of Health, Western Australia.