Ms Siyuan Tao1, Ms Linzhi Cheng1, Ms Jingwen Li1, Mr Wenzhi Huang1, Ms Linwen Guo1, Mr Bo Zhou2, Mrs. Jing Huang1, Mr Jian Peng2, Mr Yi Chen1, Mr Fu Qiao1
1West China Hospital of Sichuan University, Chengdu, China, 2iMEDWAY Technology Co. Ltd, Chengdu, China
Biography:
Current PhD candidate in Public Health, Infection Control Specialist at the Department of Healthcare-Associated Infection Management, West China Hospital, Sichuan University.
Primary responsibilities include surveillance and epidemiological investigations of hospital-acquired infections.
Abstract:
Introduction
Central venous catheters (CVCs) are widely used but carry risks of CLABSIs, which threaten patient safety. While previous CLABSI studies have primarily focused on ICUs, we conducted a hospital-wide prospective investigation using an integrated information system. This study tracked CLABSI outcomes and associated healthcare costs across all patients with CVCs, aiming to evaluate the burden of CLABSI from the patient perspective, with particular attention to differential impacts among patient subgroups.
Methods
This study employed a nested case-control design. Patients newly diagnosed with CLABSI between January 2023 and June 2024 were enrolled as cases, while contemporaneous catheterized patients without infection were matched 1:1 as controls using propensity score matching (PSM). We adjusted for potential confounders, including demographics, comorbidities, and treatment modalities, to assess the impact of CLABSI on length of stay (LOS), in-hospital mortality and healthcare economic burden. Additionally, stratified subgroup analyses were conducted based on patients' departments.
Result
Among 50,862 CVC patients, the incidence of CLABSI was 0.507/1000 catheter-days, predominantly caused by Gram-negative bacteria. Propensity-matched analysis (n=209 pairs) revealed CLABSI significantly prolonged hospitalization by 21 days (34 vs 13 days, P<0.001), increased mortality risk by 51% (23.92% vs 15.79%, P=0.037), and elevated direct medical costs by $14,387.57 (P<0.001). After adjusting for pre-insertion hospitalization duration (n=206 pairs), department-specific analysis demonstrated the greatest economic burdens occurred in ICU patients ($29,211.46) and internal medicine patients ($10,780.88), with all differences being statistically significant (P<0.05)
Conclusion
CLABSI significantly increases LOS and costs across all departments, highlighting the need for hospital-wide prevention strategies.